A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.

SG, Pillai; D, Ge; G, Zhu; X, Kong; KV, Shianna; AC, Need; S, Feng; CP, Hersh; P, Bakke; A, Gulsvik; A, Ruppert; Carlsen KC, Lødrup; A, Roses; W, Anderson; SI, Rennard; DA, Lomas; EK, Silverman; DB, Goldstein

doi:10.1371/journal.pgen.1000421

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A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.

Shared by NobleBlocks on Mar 20, 2009 • 12:00 AM UTC

Authors:

Pillai SG

Ge D

Zhu G

Abstract

There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of alpha(1)-antitrypsin, which is present in 1-2% of individuals with COPD. We conducted a genome-wide association study...

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