IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.

K, Sugimoto; A, Ogawa; E, Mizoguchi; Y, Shimomura; A, Andoh; AK, Bhan; RS, Blumberg; RJ, Xavier; A, Mizoguchi

doi:10.1172/jci33194

Public

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.

Shared by NobleBlocks on Feb 1, 2008 • 12:00 AM UTC

Authors:

Sugimoto K

Ogawa A

Mizoguchi E

Abstract

Expression of IL-22 is induced in several human inflammatory conditions, including inflammatory bowel disease (IBD). Expression of the IL-22 receptor is restricted to innate immune cells; however, the role of IL-22 in colitis has not yet been defined. We developed what we believe to be a novel micro...

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