The tumor suppressor p53 is degraded by the ubiquitin‐proteasome system. p53 was polyubiquitinated in the presence of E1, UbcH5 as E2 and MDM2 oncoprotein. A ubiquitin molecule bound MDM2 through sulfhydroxy bond which is characteristic of ubiquitin ligase (E3)‐ubiquitin binding. The cysteine residu...
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