Abatacept reduces levels of switched memory B cells, autoantibodies, and immunoglobulins in patients with rheumatoid arthritis.

M, Scarsi; L, Paolini; D, Ricotta; A, Pedrini; S, Piantoni; L, Caimi; A, Tincani; P, Airò

doi:10.3899/jrheum.130905

Public

Abatacept reduces levels of switched memory B cells, autoantibodies, and immunoglobulins in patients with rheumatoid arthritis.

Shared by NobleBlocks on Mar 1, 2014 • 12:00 AM UTC

Authors:

Scarsi M

Paolini L

Ricotta D

Abstract

<h4>Objective</h4>Abatacept (ABA) is a chimeric molecule, able to block the CD28-mediated costimulatory pathway. To evaluate the hypothesis that, through this mechanism of action, ABA may down-modulate the immune responses of B lymphocytes in rheumatoid arthritis (RA), we investigated the serum leve...

Subject

B lymphocytes

Rheumatoid Factor

Abatacept

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