PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.

WD, Heo; T, Inoue; WS, Park; ML, Kim; BO, Park; TJ, Wandless; T, Meyer

doi:10.1126/science.1134389

Public

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.

Shared by NobleBlocks on Nov 9, 2006 • 12:00 AM UTC

Authors:

Heo WD

Inoue T

Park WS

Abstract

Many signaling, cytoskeletal, and transport proteins have to be localized to the plasma membrane (PM) in order to carry out their function. We surveyed PM-targeting mechanisms by imaging the subcellular localization of 125 fluorescent protein-conjugated Ras, Rab, Arf, and Rho proteins. Out of 48 pro...

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