Gene-expression profiles in hereditary breast cancer.

I, Hedenfalk; D, Duggan; Y, Chen; M, Radmacher; M, Bittner; R, Simon; P, Meltzer; B, Gusterson; M, Esteller; OP, Kallioniemi; B, Wilfond; A, Borg; J, Trent; M, Raffeld; Z, Yakhini; A, Ben-Dor; E, Dougherty; J, Kononen; L, Bubendorf; W, Fehrle; S, Pittaluga; S, Gruvberger; N, Loman; O, Johannsson; H, Olsson; G, Sauter

doi:10.1056/nejm200102223440801

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Gene-expression profiles in hereditary breast cancer.

Shared by NobleBlocks on Feb 1, 2001 • 12:00 AM UTC

Authors:

Hedenfalk I

Duggan D

Chen Y

Abstract

<h4>Background</h4>Many cases of hereditary breast cancer are due to mutations in either the BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often characteristic of the mutant gene. We hypothesized that the genes expressed by these two types of tumors are also distinctive...

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