A core metabolic enzyme mediates resistance to phosphine gas.

I Schlipalius, David; Valmas, Nicholas; G Tuck, Andrew; Jagadeesan, Rajeswaran; Ma, Li; Kaur, Ramandeep; Goldinger, Anita; Anderson, Cameron; Kuang, Jujiao; Zuryn, Steven; S Mau, Yosep; Cheng, Qiang; J Collins, Patrick; K Nayak, Manoj; Joachim Schirra, Horst; A Hilliard, Massimo; R Ebert, Paul

doi:10.1126/science.1224951

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A core metabolic enzyme mediates resistance to phosphine gas.

Shared by NobleBlocks on Nov 9, 2012 • 12:00 AM UTC

Authors:

David I Schlipalius

Nicholas Valmas

Andrew G Tuck

Abstract

Phosphine is a small redox-active gas that is used to protect global grain reserves, which are threatened by the emergence of phosphine resistance in pest insects. We find that polymorphisms responsible for genetic resistance cluster around the redox-active catalytic disulfide or the dimerization in...

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