Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.

Wild, Philipp; Farhan, Hesso; G McEwan, David; Wagner, Sebastian; V Rogov, Vladimir; R Brady, Nathan; Richter, Benjamin; Korac, Jelena; Waidmann, Oliver; Choudhary, Chunaram; Dötsch, Volker; Bumann, Dirk; Dikic, Ivan

doi:10.1126/science.1205405

Public

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.

Shared by NobleBlocks on Jul 8, 2011 • 12:00 AM UTC

Authors:

Philipp Wild

Hesso Farhan

David G McEwan

Abstract

Selective autophagy can be mediated via receptor molecules that link specific cargoes to the autophagosomal membranes decorated by ubiquitin-like microtubule-associated protein light chain 3 (LC3) modifiers. Although several autophagy receptors have been identified, little is known about mechanisms ...

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