Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues.

Fowlkes, J.; Thrailkill, K.; Lumpkin, C.; C. Bunn, R.; Kemp, S.; Rotella, C.; Mannucci, E.; Monami, M.; Cresci, B.; Colombini, A.; Pala, L.; Balzi, D.; Gori, F.; Chiasserini, V.; Marchionni, N.; Mastrandrea, L.; Wactawski‐Wende, J.; Donahue, R.; Hovey, K.; Clark, A.; Quattrin, T.; Biol, E.; K N Ealey, Med; Kaludjerovic, J.; C. Archer, M.; Ward, W.; Reinwald, S.; Peterson, R.; Allen, M.; Burr, D.; Weng, T.; Mao, F.; Wang, Y.; Sun, Q.; Li, R.; Yang, G.; Zhang, X.; Luo, J.; Feng, Ghen; Yang, X.

doi:10.1152/AJPENDO.00159.2005

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Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues

Shared by NobleBlocks on Nov 1, 2005 • 12:00 AM UTC

Authors:

Kathryn M. Thrailkill

Charles K. Lumpkin

R. Clay Bunn

Abstract

Diabetic osteoporosis is increasingly recognized as a significant comorbidity of type 1 diabetes mellitus. In contrast, type 2 diabetes mellitus is more commonly associated with modest increases in bone mineral density for age. Despite this dichotomy, clinical, in vivo, and in vitro data uniformly s...

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