Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism.

L, Nielsen; R, Khurana; A, Coats; S, Frokjaer; J, Brange; S, Vyas; VN, Uversky; AL, Fink

doi:10.1021/bi002555c

Public

Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism.

Shared by NobleBlocks on May 1, 2001 • 12:00 AM UTC

Authors:

Nielsen L

Khurana R

Coats A

Abstract

In the search for the molecular mechanism of insulin fibrillation, the kinetics of insulin fibril formation were studied under different conditions using the fluorescent dye thioflavin T (ThT). The effect of insulin concentration, agitation, pH, ionic strength, anions, seeding, and addition of 1-ani...

Discussions