The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.

D, Gao; S, Nong; X, Huang; Y, Lu; H, Zhao; Y, Lin; Y, Man; S, Wang; J, Yang; J, Li

doi:10.1074/jbc.m110.128694

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The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.

Shared by NobleBlocks on Jul 20, 2010 • 12:00 AM UTC

Authors:

Gao D

Nong S

Huang X

Abstract

Elevated plasma free fatty acid (FFA) levels in obesity may play a pathogenic role in the development of insulin resistance. However, molecular mechanisms linking FFA to insulin resistance remain poorly understood. Oxidative stress acts as a link between FFA and hepatic insulin resistance. NADPH oxi...

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