A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Boussif, O; Lezoualc'h, F; A Zanta, M; D Mergny, M; Scherman, D; Demeneix, B; P Behr, J

doi:10.1073/pnas.92.16.7297

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Shared by NobleBlocks on Aug 1, 1995 • 12:00 AM UTC

Authors:

O Boussif

F Lezoualc'h

M A Zanta

Abstract

Several polycations possessing substantial buffering capacity below physiological pH, such as lipopolyamines and polyamidoamine polymers, are efficient transfection agents per se--i.e., without the addition of cell targeting or membrane-disruption agents. This observation led us to test the cationic...

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