Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles.

F, Dabertrand; RM, Hannah; JM, Pearson; DC, Hill-Eubanks; JE, Brayden; MT, Nelson

doi:10.1038/jcbfm.2013.9

Public

Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles.

Shared by NobleBlocks on Feb 6, 2013 • 12:00 AM UTC

Authors:

Dabertrand F

Hannah RM

Pearson JM

Abstract

It has been proposed that prostaglandin E(2) (PGE(2)) is released from astrocytic endfeet to dilate parenchymal arterioles through activation of prostanoid (EP(4)) receptors during neurovascular coupling. However, the direct effects of PGE(2) on isolated parenchymal arterioles have not been tested. ...

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