Identification of TRIM22 single nucleotide polymorphisms associated with loss of inhibition of HIV-1 transcription and advanced HIV-1 disease.

S, Ghezzi; L, Galli; A, Kajaste-Rudnitski; F, Turrini; S, Marelli; D, Toniolo; C, Casoli; A, Riva; G, Poli; A, Castagna; E, Vicenzi

doi:10.1097/01.aids.0000432474.76873.5f

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Identification of TRIM22 single nucleotide polymorphisms associated with loss of inhibition of HIV-1 transcription and advanced HIV-1 disease.

Shared by NobleBlocks on Sep 1, 2013 • 12:00 AM UTC

Authors:

Ghezzi S

Galli L

Kajaste-Rudnitski A

Abstract

<h4>Objective(s)</h4>Tripartite motif-containing 22 (TRIM22) is an interferon-induced protein that inhibits HIV-1 transcription and replication in vitro. Two single nucleotide missense polymorphisms rs7935564A/G (SNP-1) and rs1063303C/G (SNP-2) characterize the coding sequence of human TRIM22 gene. ...

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