PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

Yoo, Seung-Hee; Yamazaki, Shin; L. Lowrey, Phillip; Shimomura, Kazuhiro; H. Ko, Caroline; D. Buhr, Ethan; M. Siepka, Sandra; Hong, Hee-Kyung; Jun Oh, Won; Joon Yoo, Ook; Menaker, Michael; S. Takahashi, Joseph

doi:10.1073/pnas.0308709101

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PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

Shared by NobleBlocks on Feb 12, 2004 • 12:00 AM UTC

Authors:

Seung-Hee Yoo

Shin Yamazaki

Phillip L. Lowrey

Abstract

Mammalian circadian rhythms are regulated by the suprachiasmatic nucleus (SCN), and current dogma holds that the SCN is required for the expression of circadian rhythms in peripheral tissues. Using a PERIOD2::LUCIFERASE fusion protein as a real-time reporter of circadian dynamics in mice, we report ...

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