Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies.

Abnormal neuronal aggregation of alpha-synuclein is implicated in the development of many neurological disorders, including Parkinson disease and dementia with Lewy bodies. Glial cells also show extensive alpha-synuclein pathology and may contribute to disease progression. However, the mechanism tha... View More