Lymphoproliferative Disorders with Early Lethality in Mice Deficient in
            <i>Ctla-4</i>

Waterhouse, Paul; M. Penninger, Josef; Timms, Emma; Wakeham, Andrew; Shahinian, Arda; P. Lee, Kelvin; B. Thompson, Craig; Griesser, Henrik; W. Mak, Tak

doi:10.1126/science.270.5238.985

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Lymphoproliferative Disorders with Early Lethality in Mice Deficient in <i>Ctla-4</i>

Shared by NobleBlocks on Nov 10, 1995 • 12:00 AM UTC

Authors:

Paul Waterhouse

Josef M. Penninger

Emma Timms

Abstract

The role of the cell-surface molecule CTLA-4 in the regulation of T cell activation has been controversial. Here, lymph nodes and spleens of CTLA-4-deficient mice accumulated T cell blasts with up-regulated activation markers. These blast cells also infiltrated liver, heart, lung, and pancreas tissu...

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