Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

D, Marez; M, Legrand; N, Sabbagh; Guidice JM, Lo; C, Spire; JJ, Lafitte; UA, Meyer; F, Broly

doi:10.1097/00008571-199706000-00004

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Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

Shared by NobleBlocks on Jun 1, 1997 • 12:00 AM UTC

Authors:

Marez D

Legrand M

Sabbagh N

Abstract

The polymorphic cytochrome P450 CYP2D6 is involved in the metabolism of various drugs of wide therapeutic use and is a presumed susceptibility factor for certain environmentally-induced diseases. Our aim was to define the mutations and alleles of the CYP2D6 gene and to evaluate their frequencies in ...

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