Modulation of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11betaHSD1 inhibitor.

R, Courtney; PM, Stewart; M, Toh; MN, Ndongo; RA, Calle; B, Hirshberg

doi:10.1210/jc.2007-1912

Public

Modulation of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11betaHSD1 inhibitor.

Shared by NobleBlocks on Nov 6, 2007 • 12:00 AM UTC

Authors:

Courtney R

Stewart PM

Toh M

Abstract

<h4>Context</h4>11beta-Hydroxysteroid dehydrogenase type 1 (11betaHSD1) is a promising target for the treatment of type 2 diabetes mellitus. 11betaHSD1 catalyzes the intracrine conversion of inactive cortisone to the active glucocorticoid cortisol.<h4>Objective</h4>Demonstrating inhibition of 11beta...

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