Female sex and estrogen receptor-β attenuate cardiac remodeling and apoptosis in pressure overload

Fliegner, Daniela; Schubert, Carola; Penkalla, Adam; Witt, Henning; Kararigas, George; Dworatzek, Elke; Staub, Eike; Martus, Peter; Ruiz Noppinger, Patricia; Kintscher, Ulrich; Gustafsson, Jan-Åke; Regitz-Zagrosek, Vera

doi:10.1152/ajpregu.00825.2009

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Female sex and estrogen receptor-β attenuate cardiac remodeling and apoptosis in pressure overload

Shared by NobleBlocks on Jun 1, 2010 • 12:00 AM UTC

Authors:

Daniela Fliegner

Carola Schubert

Adam Penkalla

Abstract

We investigated sex differences and the role of estrogen receptor-β (ERβ) on myocardial hypertrophy in a mouse model of pressure overload. We performed transverse aortic constriction (TAC) or sham surgery in male and female wild-type (WT) and ERβ knockout (ERβ −/− ) mice. All mice were characterized...

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