Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.

Heusden J, Van; Ginckel R, Van; H, Bruwiere; P, Moelans; B, Janssen; W, Floren; der Leede BJ, van; Dun J, van; G, Sanz; M, Venet; L, Dillen; Hove C, Van; G, Willemsens; M, Janicot; W, Wouters

doi:10.1038/sj.bjc.6600056

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Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.

Shared by NobleBlocks on Feb 1, 2002 • 12:00 AM UTC

Authors:

Van Heusden J

Van Ginckel R

Bruwiere H

Abstract

All-trans-retinoic acid is a potent inhibitor of cell proliferation and inducer of differentiation. However, the clinical use of all-trans-retinoic acid in the treatment of cancer is significantly hampered by its toxicity and the prompt emergence of resistance, believed to be caused by increased all...

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