Chromatin targeting of de novo DNA methyltransferases by the PWWP domain.

YZ, Ge; MT, Pu; H, Gowher; HP, Wu; JP, Ding; A, Jeltsch; GL, Xu

doi:10.1074/jbc.m312296200

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Chromatin targeting of de novo DNA methyltransferases by the PWWP domain.

Shared by NobleBlocks on Mar 3, 2004 • 12:00 AM UTC

Authors:

Ge YZ

Pu MT

Gowher H

Abstract

DNA methylation patterns of mammalian genomes are generated in gametogenesis and early embryonic development. Two de novo DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the process. Both enzymes contain a long N-terminal regulatory region linked to a conserved C-terminal domain respo...

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