Interaction of the antiarrhythmic agents SR 33589 and amiodarone with the beta-adrenoceptor and adenylate cyclase in rat heart.

P, Chatelain; L, Meysmans; JR, Mattéazzi; P, Beaufort; M, Clinet

doi:10.1111/j.1476-5381.1995.tb16397.x

Public

Interaction of the antiarrhythmic agents SR 33589 and amiodarone with the beta-adrenoceptor and adenylate cyclase in rat heart.

Shared by NobleBlocks on Oct 1, 1995 • 12:00 AM UTC

Authors:

Chatelain P

Meysmans L

Mattéazzi JR

Abstract

1. The effects of SR 33589 and amiodarone on the cardiac beta-adrenoceptor were studied in vitro and after chronic treatment by means of [125I]-(-)-iodocyanopindolol ([125I]-(-)-CYP) binding and measurement of adenylate cyclase activity. 2. Binding of [125I]-(-)-CYP was inhibited in a dose-dependent...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!