Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis.

JH, Distler; A, Jüngel; M, Pileckyte; J, Zwerina; BA, Michel; RE, Gay; O, Kowal-Bielecka; M, Matucci-Cerinic; G, Schett; HH, Marti; S, Gay; O, Distler

doi:10.1002/art.23074

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Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis.

Shared by NobleBlocks on Dec 1, 2007 • 12:00 AM UTC

Authors:

Distler JH

Jüngel A

Pileckyte M

Abstract

<h4>Objective</h4>Insufficient angiogenesis with tissue ischemia and accumulation of extracellular matrix are hallmarks of systemic sclerosis (SSc). Based on the severely decreased oxygen levels in the skin of patients with SSc, we aimed to investigate the role of hypoxia in the pathogenesis of SSc....

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