Relationship between 5-fluorouracil (5-FU) dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5-FU

Gamelin, Érick; Danquechin‐Dorval, E; Dumesnil, Y.; Maillart, P.; Goudier, Marie-Josèphe; Burtin, Pascal; Delva, R.; Lortholary, Alain; Gesta, Paul; Larra, F

doi:10.1002/(sici)1097-0142(19960201)77:3<441::aid-cncr4>3.0.co;2-n

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Relationship between 5-fluorouracil (5-FU) dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5-FU

Published in Cancer • Feb 1, 1996

Authors:

Érick Gamelin

E Danquechin‐Dorval

Y. Dumesnil

Abstract

BACKGROUND: A phase II prospective trial was carried out to study the concept of 5-fluorouracil (5-FU) dose-intensity in patients with advanced colorectal cancer. Forty patients were treated with 5-FU plus leucovorin (LV), with individually increasing doses of 5-FU. A 5-FU pharmacokinetic follow up ...

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Open Access

Subject

Medicine

Fluorouracil

Toxicity

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