Population pharmacokinetics of isoniazid in the treatment of Mycobacterium tuberculosis among Asian and African elephants (Elephas maximus and Loxodonta africana)

N. Maslow, Joel; K. Mikota, Susan; Zhu, Min; Isaza, Ramiro; R. PEDDIE, L.; Dunker, Freeland; Peddie, J.; S. Riddle, Heidi; A. Peloquin, Charles

doi:10.1111/j.1365-2885.2004.00619.x

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Population pharmacokinetics of isoniazid in the treatment of Mycobacterium tuberculosis among Asian and African elephants (Elephas maximus and Loxodonta africana)

Published in Journal of Veterinary Pharmacology and Therapeutics • Feb 1, 2005

Authors:

Joel N. Maslow

Susan K. Mikota

Min Zhu

Abstract

We recently described the clinical presentation and treatment of 18 elephants from six herds infected with TB. Treatment protocols and methods varied between herds to include both oral and rectal dosing using multiple drug doses and formulations. In this paper we present information regarding the ph...

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Elephas

Isoniazid

Medicine

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Population pharmacokinetics of isoniazid in the treatment of <i>Mycobacterium tuberculosis</i> among Asian and African elephants (<i>Elephas maximus</i> and <i>Loxodonta africana</i>)

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