Exploiting the vitamin B12 pathway to enhance oral drug delivery via polymeric micelles.

MF, Francis; M, Cristea; FM, Winnik

doi:10.1021/bm0503165

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Exploiting the vitamin B12 pathway to enhance oral drug delivery via polymeric micelles.

Shared by NobleBlocks on Sep 1, 2005 • 12:00 AM UTC

Authors:

Francis MF

Cristea M

Winnik FM

Abstract

Vitamin B12 (VB12)-modified dextran-g-polyethyleneoxide cetyl ether (DEX-g-PEO-C16) was synthesized by linking VB12 residues to a DEX-g-PEO-C16 copolymer via a 2,2'-(ethylenedioxy)bis(ethylamine) spacer. The level of VB12 substitution on the DEX-g-PEO-C16 copolymer reached 1.68% (w/w). In aqueous so...

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