Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain.

Calvo, R; J Obregón, M; Ruiz de Oña, C; Escobar del Rey, F; Morreale de Escobar, G

doi:10.1172/jci114790

Public

Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain.

Shared by NobleBlocks on Sep 1, 1990 • 12:00 AM UTC

Authors:

R Calvo

M J Obregón

C Ruiz de Oña

Abstract

To study the protective effects of maternal thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in congenital hypothyroidism, we gave pregnant rats methimazole (MMI), an antithyroid drug that crosses the placenta, and infused them with three different doses of T4 or T3. The concentrations of both T4 and...

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