Genetic variants of the organic cation transporter 2 influence the disposition of metformin.

IS, Song; HJ, Shin; EJ, Shim; IS, Jung; WY, Kim; JH, Shon; JG, Shin

doi:10.1038/clpt.2008.61

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Genetic variants of the organic cation transporter 2 influence the disposition of metformin.

Shared by NobleBlocks on Apr 9, 2008 • 12:00 AM UTC

Authors:

Song IS

Shin HJ

Shim EJ

Abstract

Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant dif...

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