Regulation of Cell Death Protease Caspase-9 by Phosphorylation

H. Cardone, Michael; Roy, Natalie; R. Stennicke, Henning; S. Salvesen, Guy; F. Franke, Thomas; Stanbridge, Eric; Frisch, Steven; C. Reed, John

doi:10.1126/science.282.5392.1318

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Regulation of Cell Death Protease Caspase-9 by Phosphorylation

Shared by NobleBlocks on Nov 13, 1998 • 12:00 AM UTC

Authors:

Michael H. Cardone

Natalie Roy

Henning R. Stennicke

Abstract

Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro–caspase-9 (pro-Casp9) in cells. Cytochrome c–induced proteolytic processing of pro-Casp9 was defective in cytosolic extracts from ...

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