Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells.

Wang, Jinheng; Hendrix, An; Hernot, Sophie; Lemaire, Miguel; De Bruyne, Elke; Van Valckenborgh, Els; Lahoutte, Tony; De Wever, Olivier; Vanderkerken, Karin; Menu, Eline

doi:10.1182/blood-2014-03-562439

Public

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells.

Shared by NobleBlocks on Jul 24, 2014 • 12:00 AM UTC

Authors:

Jinheng Wang

An Hendrix

Sophie Hernot

Abstract

The interplay between bone marrow stromal cells (BMSCs) and multiple myeloma (MM) cells performs a crucial role in MM pathogenesis by secreting growth factors, cytokines, and extracellular vesicles. Exosomes are membranous vesicles 40 to 100 nm in diameter constitutively released by almost all cell ...

Discussions