Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton.

T, Igakura; JC, Stinchcombe; PK, Goon; GP, Taylor; JN, Weber; GM, Griffiths; Y, Tanaka; M, Osame; CR, Bangham

doi:10.1126/science.1080115

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Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton.

Shared by NobleBlocks on Feb 13, 2003 • 12:00 AM UTC

Authors:

Igakura T

Stinchcombe JC

Goon PK

Abstract

Cell contact is required for efficient transmission of human T cell leukemia virus- type 1 (HTLV-I) between cells and between individuals, because naturally infected lymphocytes produce virtually no cell-free infectious HTLV-I particles. However, the mechanism of cell-to-cell spread of HTLV-I is not...

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