Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma.

A, Mazzocca; E, Fransvea; F, Dituri; L, Lupo; S, Antonaci; G, Giannelli

doi:10.1002/hep.23285

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Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma.

Shared by NobleBlocks on Feb 1, 2010 • 12:00 AM UTC

Authors:

Mazzocca A

Fransvea E

Dituri F

Abstract

<h4>Unlabelled</h4>Tumor-stroma interactions in hepatocellular carcinoma (HCC) are of key importance to tumor progression. In this study, we show that HCC invasive cells produce high levels of connective tissue growth factor (CTGF) and generate tumors with a high stromal component in a xenograft mod...

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