Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.

DQ, Li; Z, Chen; XJ, Song; L, Luo; SC, Pflugfelder

doi:10.1167/iovs.04-0299

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Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.

Shared by NobleBlocks on Dec 1, 2004 • 12:00 AM UTC

Authors:

Li DQ

Chen Z

Song XJ

Abstract

<h4>Purpose</h4>To investigate whether exposure of human corneal epithelial cells to hyperosmotic stress activates the c-Jun NH(2)-terminal kinase (JNK) stress-activated protein kinase (SAPK) pathway, and stimulates production of the matrix metalloproteinases (MMPs): gelatinase (MMP-9), collagenases...

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