Multiple functions of p27(Kip1) and its alterations in tumor cells: a review.

A, Sgambato; A, Cittadini; B, Faraglia; IB, Weinstein

doi:10.1002/(sici)1097-4652(200004)183:1<18::aid-jcp3>3.0.co;2-s

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Multiple functions of p27(Kip1) and its alterations in tumor cells: a review.

Shared by NobleBlocks on Apr 1, 2000 • 12:00 AM UTC

Authors:

Sgambato A

Cittadini A

Faraglia B

Abstract

Cyclin-dependent kinases (CDKs), together with cyclins, their regulatory subunits, govern cell-cycle progression in eukaryotic cells. p27(Kip1) is a member of a family of CDK inhibitors (CDIs) that bind to cyclin/CDK complexes and arrest cell division. There is considerable evidence that p27(Kip1) p...

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