Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons.

Wang, Shuyan; Wang, Bin; Pan, Na; Fu, Linlin; Wang, Chaodong; Song, Gongru; An, Jing; Liu, Zhongfeng; Zhu, Wanwan; Guan, Yunqian; David Xu, Zhi-Qing; Chan, Piu; Chen, Zhiguo; Alex Zhang, Y

doi:10.1038/srep09232

Public

Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons.

Shared by NobleBlocks on Mar 18, 2015 • 12:00 AM UTC

Authors:

Shuyan Wang

Bin Wang

Na Pan

Abstract

It remains a challenge to differentiate human induced pluripotent stem cells (iPSCs) or embryonic stem (ES) cells to Purkinje cells. In this study, we derived iPSCs from human fibroblasts and directed the specification of iPSCs first to Purkinje progenitors, by adding Fgf2 and insulin to the embryoi...

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