Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs

Iwasa, Tsutomu; Okamoto, Isamu; Takezawa, Ken; Yamanaka, Kenzo; Nakahara, Takahito; Kita, Aya; Koutoku, Hiroshi; Sasamata, Masao; Hatashita, Erina; Yamada, Yuki; Kuwata, Kiyoko; Fukuoka, M.; Nakagawa, Kazuhiko

doi:10.1038/sj.bjc.6605713

Public

Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs

Shared by NobleBlocks on Jun 1, 2010 • 12:00 AM UTC

Authors:

Tsutomu Iwasa

Isamu Okamoto

Ken Takezawa

Abstract

BACKGROUND: Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We have now investigated the effects of the combination of YM155, a novel small-molecule inhibitor of survivin expression, and platinum compounds (cisplatin and carboplatin) on hu...

Subject

Survivin

Carboplatin

Cisplatin

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