A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910.

R de Jonge, Marc; H M Koymans, Luc; E G Guillemont, Jérôme; Koul, Anil; Andries, Koen

doi:10.1002/prot.21376

Public

A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910.

Shared by NobleBlocks on Jun 1, 2007 • 12:00 AM UTC

Authors:

Marc R de Jonge

Luc H M Koymans

Jérôme E G Guillemont

Abstract

Diarylquinolines (DARQs) are a new class of potent inhibitors of the ATPase of Mycobacterium tuberculosis. We have created a homology model of a binding site for this class of compounds located on the contact area of the a-subunit (gene atpB) and c-subunits (gene atpE) of Mycobacterium tuberculosis ...

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