Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis.

SB, Vasamsetti; S, Karnewar; AK, Kanugula; AR, Thatipalli; JM, Kumar; S, Kotamraju

doi:10.2337/db14-1225

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Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis.

Shared by NobleBlocks on Dec 31, 2014 • 12:00 AM UTC

Authors:

Vasamsetti SB

Karnewar S

Kanugula AK

Abstract

Monocyte-to-macrophage differentiation is a critical event that accentuates atherosclerosis by promoting an inflammatory environment within the vessel wall. In this study, we investigated the molecular mechanisms responsible for monocyte-to-macrophage differentiation and, subsequently, the effect of...

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