Pharmacological activation of NQO1 increases NAD⁺ levels and attenuates cisplatin-mediated acute kidney injury in mice.

Oh, Gi-Su; Kim, Hyung-Jin; Choi, Jae-Hyuck; Shen, Aihua; Choe, Seong-Kyu; Karna, Anzani; Hoon Lee, Seung; Jo, Hyang-Jeong; Yang, Sei-Hoon; Hwan Kwak, Tae; Lee, Chul-Ho; Park, Raekil; So, Hong-Seob

doi:10.1038/ki.2013.330

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Pharmacological activation of NQO1 increases NAD⁺ levels and attenuates cisplatin-mediated acute kidney injury in mice.

Shared by NobleBlocks on Mar 1, 2014 • 12:00 AM UTC

Authors:

Gi-Su Oh

Hyung-Jin Kim

Jae-Hyuck Choi

Abstract

Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors. In addition to its antitumor activity, cisplatin affects normal cells and may induce adverse effects, such as ototoxicity, nephrotoxicity, and neuropathy. Various mechanisms, such as DNA adduct formation, mitochon...

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