Enhanced insulin sensitivity in mice lacking ganglioside GM3.

T, Yamashita; A, Hashiramoto; M, Haluzik; H, Mizukami; S, Beck; A, Norton; M, Kono; S, Tsuji; JL, Daniotti; N, Werth; R, Sandhoff; K, Sandhoff; RL, Proia

doi:10.1073/pnas.0635898100

Public

Enhanced insulin sensitivity in mice lacking ganglioside GM3.

Shared by NobleBlocks on Mar 10, 2003 • 12:00 AM UTC

Authors:

Yamashita T

Hashiramoto A

Haluzik M

Abstract

Gangliosides are sialic acid-containing glycosphingolipids that are present on all mammalian plasma membranes where they participate in recognition and signaling activities. We have established mutant mice that lack GM3 synthase (CMP-NeuAc:lactosylceramide alpha2,3-sialyltransferase; EC 2.4.99.-). T...

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