Folliculin encoded by the
            <i>BHD</i>
            gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

Baba, Masaya; Hong, Seung-Beom; Sharma, Nirmala; B. Warren, Michelle; L. Nickerson, Michael; Iwamatsu, Akihiro; Esposito, Dominic; K. Gillette, William; F. Hopkins, Ralph; L. Hartley, James; Furihata, Mutsuo; Oishi, Shinya; Zhen, Wei; R. Burke, Terrence; Marston Linehan, W.; S. Schmidt, Laura; Zbar, Berton

doi:10.1073/pnas.0603781103

Public

Folliculin encoded by the <i>BHD</i> gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

Shared by NobleBlocks on Oct 17, 2006 • 12:00 AM UTC

Authors:

Masaya Baba

Seung-Beom Hong

Nirmala Sharma

Abstract

Birt–Hogg–Dubé syndrome, a hamartoma disorder characterized by benign tumors of the hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD(FLCN) gene, which encodes a tumor-suppressor protein, folliculin (FLCN), with unknown function. The tumor-suppressor protein...

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