Paclitaxel-loaded PLGA nanoparticles surface modified with transferrin and Pluronic((R))P85, an in vitro cell line and in vivo biodistribution studies on rat model.

N, Shah; K, Chaudhari; P, Dantuluri; RS, Murthy; S, Das

doi:10.1080/10611860903046628

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Paclitaxel-loaded PLGA nanoparticles surface modified with transferrin and Pluronic((R))P85, an in vitro cell line and in vivo biodistribution studies on rat model.

Shared by NobleBlocks on Aug 1, 2009 • 12:00 AM UTC

Authors:

Shah N

Chaudhari K

Dantuluri P

Abstract

The development of multidrug resistance (due to drug efflux by P-glycoproteins) is a major drawback with the use of paclitaxel (PTX) in the treatment of cancer. The rationale behind this study is to prepare PTX nanoparticles (NPs) for the reversal of multidrug resistance based on the fact that PTX l...

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