Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms.

ME, Bernardo; N, Zaffaroni; F, Novara; AM, Cometa; MA, Avanzini; A, Moretta; D, Montagna; R, Maccario; R, Villa; MG, Daidone; O, Zuffardi; F, Locatelli

doi:10.1158/0008-5472.can-06-4690

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Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms.

Shared by NobleBlocks on Oct 1, 2007 • 12:00 AM UTC

Authors:

Bernardo ME

Zaffaroni N

Novara F

Abstract

Significant improvement in the understanding of mesenchymal stem cell (MSC) biology has opened the way to their clinical use. However, concerns regarding the possibility that MSCs undergo malignant transformation have been raised. We investigated the susceptibility to transformation of human bone ma...

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