Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction.

M, Sato; Y, Muragaki; S, Saika; AB, Roberts; A, Ooshima

doi:10.1172/jci19270

Public

Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction.

Shared by NobleBlocks on Nov 1, 2003 • 12:00 AM UTC

Authors:

Sato M

Muragaki Y

Saika S

Abstract

Tubulointerstitial fibrosis is the final common result of a variety of progressive injuries leading to chronic renal failure. Transforming growth factor-beta (TGF-beta) is reportedly upregulated in response to injurious stimuli such as unilateral ureteral obstruction (UUO), causing renal fibrosis as...

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