Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells.

HW, Jung; YS, Chung; YS, Kim; YK, Park

doi:10.1038/emm.2007.78

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Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells.

Shared by NobleBlocks on Dec 1, 2007 • 12:00 AM UTC

Authors:

Jung HW

Chung YS

Kim YS

Abstract

Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. Here, we investigated whether celastrol, which has been used as a potent anti-inflammatory and anti-oxidative agent in Chinese medicine, atten...

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