A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

Higashiyama, Shigeki; A. Abraham, Judith; Miller, Judy; C. Fiddes, John; Klagsbrun, Michael

doi:10.1126/science.1840698

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A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

Shared by NobleBlocks on Feb 22, 1991 • 12:00 AM UTC

Authors:

Shigeki Higashiyama

Judith A. Abraham

Judy Miller

Abstract

Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal...

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