Glanzmann thrombasthenia: deficient binding of von Willebrand factor to thrombin-stimulated platelets.

Glanzmann thrombasthenia is an inherited bleeding disorder characterized by the failure of platelets to aggregate in response to almost all stimuli. However, thrombasthenic platelets will aggregate with bovine and porcine von Willebrand factor (vWF) and will show normal ristocetin-induced binding an... View More