ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury.

T, Nakazawa; M, Shimura; M, Ryu; K, Nishida; G, Pagès; J, Pouysségur; S, Endo

doi:10.1002/jnr.21472

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ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury.

Shared by NobleBlocks on Jan 1, 2008 • 12:00 AM UTC

Authors:

Nakazawa T

Shimura M

Ryu M

Abstract

Excitotoxicity has been implicated in several ischemic diseases of the retina, including retinal vessel occlusion and diabetic retinopathy. Glutamate signaling mediated through the N-methyl-D-aspartate (NMDA) receptor contributes to ischemic cell death. The NMDA receptor antagonists MK-801 and meman...

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