Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).

SJ, Lee; BC, Jang; SW, Lee; YI, Yang; SI, Suh; YM, Park; S, Oh; JG, Shin; S, Yao; L, Chen; IH, Choi

doi:10.1016/j.febslet.2005.12.093

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Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).

Shared by NobleBlocks on Jan 9, 2006 • 12:00 AM UTC

Authors:

Lee SJ

Jang BC

Lee SW

Abstract

Majority of cancer cells upregulate co-inhibitory molecule B7-H1 which confers resistance to anti-tumor immunity, allowing cancers to escape from host immune surveillance. We addressed the molecular mechanism underlying the regulation of cancer-associated B7-H1 expression in response to interferon-g...

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